Science Advances

The PDF file includes:

• Fig. S1. Design and construction of the DNA nanoswitch.
• Fig. S2. Programmable design of the DNA nanoswitch.
• Fig. S3. Concept validation using miRNA let-7b.
• Fig. S4. Specificity and sensitivity in other miRNAs.
• Fig. S5. Mismatch detection in small RNA samples.
• Fig. S6. Protocol modification for total RNA detection.
• Fig. S7. Sensitivity of miR-206 detection from RNA extracts.
• Fig. S8. MicroRNA detection in different cell lines.
• Fig. S9. Stability of the nanoswitch after drying.
• Table S1. Comparison of miRacles assay with currently existing miRNA detection methods.

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Other Supplementary Material for this manuscript includes the following:

• Movie S1 (.mov format). Time-lapse movie of miRNA detection in 1 hour using miRacles assay.