Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Comparison of cardiolipin molecules bound to Nqo8 from coarse-grained and atomistic models.
  • Fig. S2. The structure of the membrane domain of complex I from T. thermophilus.
  • Fig. S3. Electrostatic potential surface of the bacterial and mammalian complex I.
  • Fig. S4. Global motion of complex I with and without cardiolipin.
  • Fig. S5. Projection of complex I dynamics with and without cardiolipin along the bending (PC1) and twisting (PC2) modes.
  • Table S1. Overview of all coarse-grained MD simulations.
  • Table S2. Residues within 3 Å of putative channels 1 and 2.
  • Legends for movies S1 and S2

Download PDF

Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). Cardiolipin binding to complex I from a coarse-grained simulation trajectory.
  • Movie S2 (.mov format). Cardiolipin-induced channel formation dynamics.

Files in this Data Supplement: