Science Advances

Supplementary Materials

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  • Supplementary Text
  • Table S1. Molecular clock assay reveals that RelMtb deficiency results in ongoing Mtb replication during NS.
  • Table S2. Activity of RelMtb inhibitor candidates in enzymatic assay and in whole-cell assay against nutrient-starved Mtb.
  • Table S3. X9 significantly reduced the MBC of INH (in μg/ml) against Mtb during NS.
  • Fig. S1. Δrel shows reduced growth at elevated temperature relative to its WT background strain.
  • Fig. S2. Potent compounds identified by analog search of HTS hits.
  • Fig. S3. Chemical structures of the 11 additional active compounds.
  • Fig. S4. Chemical synthetic route of X9.

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