Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Validating the Taiji framework.
  • Fig. S2. The topological properties of genetic networks.
  • Fig. S3. PageRank scores (color shade) and expression levels (circle size) of 35 constitutively active TFs across 12 tissues and eight stages.
  • Fig. S4. Identification of driver TFs in 12 tissues.
  • Fig. S5. Identification of driver TFs in early mouse embryonic development, including two-, four-, and eight-cell stages, ICM, and ESC.
  • Fig. S6. Selecting algorithms and parameters for clustering analysis.
  • Fig. S7. Transcriptional waves direct tissue differentiation during mouse embryogenesis.
  • Table S1. Driver TFs in the heart.
  • Table S2. Driver TFs in the limb.
  • Table S3. Driver TFs in the liver.
  • Table S4. Driver TFs in the lung.
  • Table S5. Driver TFs in the kidney.
  • References (40–76)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). The accession numbers of datasets analyzed in this study.
  • Data file S2 (Microsoft Excel format). Germ layer–specific TFs and their P values.
  • Data file S3 (Microsoft Excel format). PageRank scores for all TFs across different stages and tissues.
  • Data file S4 (.zip format). Chromatin interaction predictions made by EpiTensor.

Files in this Data Supplement: