Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. This colormap is used in all subsequent animations, unless a colormap is explicitly displayed in the animation.
  • Fig. S2. Parametrized MM of porcine ventricular cells (red) based on experimental microelectrode data (black).
  • Fig. S3. APD and CV restitution curves obtained from optical mapping in a Langendorff-perfused porcine heart (circles) and the fit by the MM (red line).
  • Fig. S4. APD restitution data obtained in the simulation from steady-state pacing shown in red and scatter plot of APD versus DI obtained from the whole tissue in the presence of a single spiral wave (VT, left) and during sustained fibrillation (VF, right).
  • Fig. S5. MM for rabbit with CytoD and DAM.
  • Fig. S6. Each panel shows a different scenario that was successfully modeled using WebGL.
  • Fig. S7. Parameter sweep using the OVVR model in conjunction with TP-INa current kinetics.
  • Legends for movies S1 to S13
  • Experimental measurements and fitting MMs to experimental data
  • Simulations of spiral waves with different trajectories
  • Further example of parameter space study using the OVVR model in 2D
  • Legend for Supplementary Programs

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). Linear spiral wave core trajectories seen in Fig. 1A obtained experimentally in canine right ventricle from optical mapping (top) and numerically reproduced by the OVVR model calculated using WebGL 2.0 (bottom) with m-cells and 90% of L-type calcium blockage.
  • Movie S2 (.avi format). Circular spiral wave core trajectory seen in Fig. 1B obtained experimentally in canine atria from optical mapping (top) and numerically reproduced by the OVVR model calculated using WebGL 2.0 (bottom) with m-cells.
  • Movie S3 (.mov format). EADs that are generated in a 2D slab of tissue seen in Fig. 1D from a single stimulus in the bottom left corner of the domain.
  • Movie S4 (.mov format). Evolution and breakup of a single scroll wave and its corresponding filament in a 3D slab.
  • Movie S5 (.avi format). Reproducing a single spiral wave in a porcine ventricular structure numerically (left) versus the optical mapping data obtained experimentally on a Langendorff-perfused porcine heart (right) seen in Fig. 3A.
  • Movie S6 (.avi format). Reproducing a single spiral wave on a rabbit ventricular structure numerically (left) versus the optical mapping data obtained experimentally on a Langendorff-perfused rabbit heart (right) seen in Fig. 3C.
  • Movie S7 (.mov format). Solving approximately 350 time steps of the Beeler-Reuter model (49) on a 512 × 512 grid.
  • Movie S8 (.mov format). Solving approximately 300 time steps of the TP 19-variable model on a 512 × 512 grid.
  • Movie S9 (.mov format). Solving approximately 300 time steps of the OVVR 35-variable model on a 256 × 256 grid.
  • Movie S10 (.mov format). Solving approximately 350 time steps of the Beeler-Reuter eight-variable model (49) on a 64 × 64 × 64 grid.
  • Movie S11 (.mov format). Solving approximately 70 time steps of the Beeler-Reuter eight-variable model (49) on a 128 × 128 × 128 grid.
  • Movie S12 (.mov format). Solving approximately 340 time steps of the TP 19-variable model on a 64 × 64 × 64 grid.
  • Movie S13 (.mov format). Solving approximately 170 time steps of the OVVR 35-variable model on a 64 × 64 × 64 grid.
  • Supplementary Programs. All the WebGL programs that were used in this article, as well as the copy of Abubu.js library, are included here.

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