Science Advances

The PDF file includes:

• Supplementary Materials and Methods
• Fig. S1. Schematic diagram of conjugation of polyanions to bonding of collagen fibrils.
• Fig. S2. Snapshot of the simulation of the Ca²⁺, HPO₄²⁻, and PAA system.
• Fig. S3. Conventional TEM of ruthenium red and uranyl acetate stained collagen fibrils.
• Fig. S4. High performance liquid chromatography of HPAA-collagen in various extraction media.
• Fig. S5. Particle size distribution of the mineralizing solution.
• Fig. S6. Representative TEM images of different mineralization phase of HPAA-collagen.
• Fig. S7. Conventional TEM examination of LPAA-collagen mineralized with CaP.
• Fig. S8. Molecular dynamics simulation of several collagen fibrillar strctures containing bound HPAA molecules.
• Fig. S9. Characterization of mineralized collagen fibrils.
• Fig. S10. Biocompatibility evaluation of bare collagen sponges versus HPAA-collagen sponges.
• Legends for movies S1 to S4

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Other Supplementary Material for this manuscript includes the following:

• Movie S1 (.mp4 format). Molecular dynamics simulation of aggregation of Ca²⁺ and HPO₄²⁻ in the presence of PAA.
• Movie S2 (.mp4 format). Early phase of intrafibrillar mineralization of HPAA-collagen.
• Movie S3 (.mp4 format). Middle phase of intrafibrillar mineralization of HPAA-collagen.
• Movie S4 (.mp4 format). Late phase of intrafibrillar mineralization of HPAA-collagen.