Science Advances
Supplementary Materials
The PDF file includes:
- Supplementary Materials and Methods
- Fig. S1. Schematic diagram of conjugation of polyanions to bonding of collagen fibrils.
- Fig. S2. Snapshot of the simulation of the Ca2+, HPO42−, and PAA system.
- Fig. S3. Conventional TEM of ruthenium red and uranyl acetate stained collagen fibrils.
- Fig. S4. High performance liquid chromatography of HPAA-collagen in various extraction media.
- Fig. S5. Particle size distribution of the mineralizing solution.
- Fig. S6. Representative TEM images of different mineralization phase of HPAA-collagen.
- Fig. S7. Conventional TEM examination of LPAA-collagen mineralized with CaP.
- Fig. S8. Molecular dynamics simulation of several collagen fibrillar strctures containing bound HPAA molecules.
- Fig. S9. Characterization of mineralized collagen fibrils.
- Fig. S10. Biocompatibility evaluation of bare collagen sponges versus HPAA-collagen sponges.
- Legends for movies S1 to S4
Other Supplementary Material for this manuscript includes the following:
- Movie S1 (.mp4 format). Molecular dynamics simulation of aggregation of Ca2+ and HPO42− in the presence of PAA.
- Movie S2 (.mp4 format). Early phase of intrafibrillar mineralization of HPAA-collagen.
- Movie S3 (.mp4 format). Middle phase of intrafibrillar mineralization of HPAA-collagen.
- Movie S4 (.mp4 format). Late phase of intrafibrillar mineralization of HPAA-collagen.
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