Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Atg7 deletion in forebrain GABAergic neurons by Dlx5-creERT2.
  • Fig. S2. GABARAPs mislocalized to p62+ aggregates in affected neurons of Dlx5-creERT2 and CaMKII-cre Atg7 cKO mice.
  • Fig. S3. Autophagy deficiency led to a reduction of surface GABAA receptors but no change in excitatory signaling.
  • Fig. S4. Reduction of GABAA receptors in cortical GABAergic interneurons due to compromised functions of GABARAPL2 by autophagy deficiency.
  • Fig. S5. Levels and localizations of BIG-2 and NSF were not affected by autophagy deficiency.
  • Fig. S6. GABAA receptors are not substantially localized to endosomal and lysosomal compartments in cortical GABAergic interneurons and are not altered by autophagy deficiency.
  • Fig. S7. Reduced surface GABAA receptor expression by manipulation of p62 levels.
  • Table S1. shRNA sequences used in this study.
  • Table S2. Antibodies used in this study.
  • Table S3. Patient information for frozen postmortem human brain samples.

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