Science Advances

Supplementary Materials

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  • Fig. S1. The reprogramming factors activate the three major unfolded protein responses during reprogramming.
  • Fig. S2. The reprogramming factors activate all the three branches of the UPRER during reprogramming.
  • Fig. S3. Activation of the UPRER and reactivation of the endogenous pluripotent genes during the different cellular reprogramming stages using fibroblast-like HSPA5-GFP cells.
  • Fig. S4. Modulation of the UPRER and its impact on cell proliferation.
  • Fig. S5. Derived iPSCs stain positive for pluripotent genes.
  • Fig. S6. Episomal reprogramming of fibroblasts by XBP1s overexpression.
  • Fig. S7. Activation of the UPRER in stem cells prevents their proper spreading and cell sorting strategy.
  • Fig. S8. Levels of UPRER activation are predictive of the reprogramming efficiency using 3F.
  • Table S1. Transcriptome analysis of UPRER genes in fibroblasts, iPSCs, and ESCs.
  • Table S2. List of reagents used.
  • References (3436)

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