Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Tlr4 sequencing in rd1 mice.
  • Fig. S2. Gpr179 sequencing in rd1 mice.
  • Fig. S3. Examination of potential mutations induced by virus insertion in Pde6b cDNA from the rd1 mice.
  • Fig. S4. Representative images of retinal electroporation.
  • Fig. S5. Sequencing results at predicted off-target sites.
  • Fig. S6. Representative section images of mouse retinae.
  • Fig. S7. Visual function of wild-type and rd1-Cas9/RecA mice evaluated by ERG with different blockers at P14.
  • Fig. S8. Visual function of wild-type, cDTA, Gnat1−/−, rd1-Cas9/RecA, rd1-Cas9, and rd1/cDTA-Cas9/RecA mice evaluated by ERG with STBs in different intensities at P14.
  • Fig. S9. Immunostaining with rod photoreceptor marker in rd1 and rd1/cDTA mice at P20.
  • Table S1. DNA sequences of primers and oligos.
  • Table S2. Potential off-target sites from mouse coding sequence predicted by the Off-Spotter database.

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