Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Conditional knockout of Runx1 induces Runx3 overexpression in the Runx1fl/fl;Nf1fl/fl;DhhCre mouse neurofibromas.
  • Fig. S2. Runx1/Runx3 drive neurofibromagenesis by activating oncogenic pathways and reprogramming the neuronal and immune systems.
  • Fig. S3. ChIP-seq and ATAC-seq revealed the potential targets of Runx.
  • Fig. S4. Gene expression of SC differentiation/myelination markers and RUNX family genes from existing transcriptomic data.
  • Fig. S5. Gene expression of other known Pmp22 regulator in RNA-seq.
  • Fig. S6. CRISPR-Cas9 approach deletes five putative Runx-binding sites in Pmp22 gene.
  • Legend for table S1

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Differential gene level expression change in Runx1fl/fl;Runx3fl/fl;Nf1fl/fl;DhhCre mouse tumors versus Nf1fl/fl;DhhCre mouse tumors (FDR P < 0.05, |fold change| > 2×).

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