Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Ectopic expression of p63 in fibroblasts leads to establishment of enhancers and downstream up-regulation of inflammation and epithelial genes.
  • Fig. S2. Ectopic coexpression of p63 and KLF4 leads to establishment of keratinocyte-specific enhancers and up-regulation of epithelial genes.
  • Fig. S3. Mutations in p63 disrupt enhancer establishment and lead to loss of up-regulation of key keratinocyte-specific genes.
  • Fig. S4. Heatmap of genes regulated by p63 + KLF4 that have been strongly linked to CL/P in murine KD and KO models.
  • Fig. S5. p63/KLF4 peaks colocalize strongly with highly associated CL/P SNPs near IRF6, RHPN2, and GPATCH1.
  • Legends for tables S1 to S4

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Genes up-regulated in fibroblasts + p63 compared to control fibroblasts (fold change > 1.5; FDR < 0.05).
  • Table S2 (Microsoft Excel format). Genes up-regulated in fibroblasts + p63 + KLF4 compared to control fibroblasts (fold change > 1.5; FDR < 0.05).
  • Table S3 (Microsoft Excel format). Mutations in p63 disrupt up-regulation of keratinocyte-specific genes.
  • Table S4 (Microsoft Excel format). Causal and candidate genes involved in CL/P identified in our transdifferentiation model.

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