Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Dose response of GT13072 in CIA.
  • Fig. S2. GT13072 inhibits joint destruction and induces a rise in TNF-α and IL-10 levels in serum.
  • Fig. S3. GT13072 has selective effect on IL-17A+ cells.
  • Fig. S4. cIAP1/2 inhibition down-regulates IL-17A secretion but has no effect on TNF-α or IFN-γ.
  • Fig. S5. GT13072 selectively inhibits IL-17A+ expression.
  • Fig. S6. Multiple cIAP-targeting compounds inhibit IL-17A secretion.
  • Fig. S7. GT13072 increases the percentage of Tregs.
  • Table S1. Anti-human antibodies used for fluorescence-activated cell sorting analysis.
  • Table S2. Anti-mouse antibodies used for fluorescence-activated cell sorting analysis.
  • Table S3. Human probes with the following Applied Biosystems assay identification numbers were used.
  • Table S4. Antibodies used for immunoblotting.

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