Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. Biochemical profile and LC-MS analysis of hsBCL9CT peptides.
  • Fig. S2. Cellular uptake, Wnt reporter, and coimmunoprecipitation analysis of hsBCL9CT peptides.
  • Fig. S3. Selectivity in multiple signaling pathways and antiproliferation assay of hsBCL9CT peptides.
  • Fig. S4. PK, toxicology, and histology analysis of hsBCL9CT-24 and hsBCL9CT-35.
  • Fig. S5. IHC staining in patient tumor tissues and PDX tumor models.
  • Fig. S6. Wnt pathway gene expression is correlated with CD4+CD25+FOXP3+ Treg cell infiltration in cancers.
  • Fig. S7. Effects of hsBCL9CT-24 treatment on anticancer immune cells.
  • Table S1. Sequences of hsBCL9CT peptides and related derivatives.
  • Table S2. PK and TK profiles of hsBCL9CT-24 and hsBCL9CT-35 in mice.
  • Table S3. Additional PK, solubility, and stability investigations with hsBCL9CT-24.

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