Science Advances

Supplementary Materials

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  • Fig. S1. AMBRA1, but not TRIM32, is required for basal autophagy in myoblast cells.
  • Fig. S2. Role of TRIM32 and AMBRA1 in autophagy induction by atrophic stimuli in muscle cells.
  • Fig. S3. Analysis of autophagy defects in TRIM32 silenced myoblasts.
  • Fig. S4. Role of Trim32 in autophagy induction by nutrient starvation in muscle cells.
  • Fig. S5. Analysis of autophagy defects in Trim32−/− mice.
  • Fig. S6. Analysis of MuRF1 and ROS levels in dexamethasone-treated muscle cells.
  • Fig. S7. Characterization of the proautophagic properties of TRIM32.
  • Fig. S8. Regulation of ULK1 activity by NEDD4L and TRIM32.
  • Fig. S9. Characterization of autophagy properties of C2.7 cells expressing TRIM32 pathological mutants.
  • Fig. S10. Defective autophagy induction in human and murine myoblast cells expressing TRIM32 pathological mutants.

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