Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Methods
  • Fig. S1. Co-encapsulation of UAMS-1 and lysostaphin in the hydrogel system does not affect bacterial viability.
  • Fig. S2. BMP-2–loaded lysostaphin-delivering hydrogels exhibit diffusion-mediated and protease-triggered release.
  • Fig. S3. Lysostaphin-delivering hydrogels eliminate infection at 1 week.
  • Fig. S4. Lysostaphin-delivering hydrogels eliminate infection at 8 weeks.
  • Fig. S5. BMP-2–loaded lysostaphin-delivering hydrogels do not show signs of systemic toxicity.
  • Fig. S6. Gating strategy for inflammatory cell profiling analysis.
  • Fig. S7. Percent of parent inflammatory cells at 1 week after implantation of BMP-2–loaded lysostaphin-delivering hydrogels.
  • Fig. S8. Percent of parent inflammatory cells at 4 weeks after implantation of BMP-2–loaded lysostaphin-delivering hydrogels.
  • Table S1. Immune cell profiling antibody characteristics.

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