Science Advances

Supplementary Materials

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  • Fig. S1. Protein geranylgeranylation has no effect on DNA virus–induced antiviral innate immune response.
  • Fig. S2. Rac1 but not RhoA or Cdc42 suppresses MAVS signaling in a protein geranylgeranylation–dependent manner.
  • Fig. S3. Protein geranylgeranylation targets Rac1 to MERC ER membranes upon RLR engagement.
  • Fig. S4. Chaperon but not the signaling function of SIGMA1R and Rac1 palmitoylation is important for anchoring Rac1 to MERC ER membranes.
  • Fig. S5. Rac1 directly engages MAVS signalosome and inhibits MAVS signaling in a protein geranylgeranylation–dependent manner.
  • Fig. S6. MERC-localized Rac1 inhibits Trim31-MAVS interaction and subsequent MAVS Lys63-linked ubiquitination, aggregation, and activation upon RNA virus infection.
  • Fig. S7. MERC-localized Rac1 promotes cleavage of Ripk1 and the association of TANK with ubiquitinated Ripk1.
  • Fig. S8. Pggt1b deficiency and Statin pretreatment in BMDMs enhance antiviral innate immune response after influenza A virus PR8 challenge.
  • Fig. S9. Graphic summary.
  • Table S1. Primers for quantitative RT-PCR.

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