Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Experimental setup.
  • Fig. S2. Reconstruction of mutational profiles using known mutational signatures.
  • Fig. S3. De novo identification of mutational signatures.
  • Fig. S4. Gene expression of important DNA repair components.
  • Table S1. Summary of all samples and the number of mutations identified per sample.
  • Table S2. Results for the validation of 569 base substitutions by capture using custom-designed probes, followed by resequencing.
  • Table S3. All identified base pair substitutions that affect protein-coding regions of the genome.

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