Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. PKA phosphorylates HEXIM1 at serine-158.
  • Fig. S2. Phosphorylation of CDK9 at serine-347 by PKA does not affect P-TEFb/HEXIM1/7SK snRNP complex assembly.
  • Fig. S3. The phosphorylation level of HEXIM1 is increased in cystic epithelial cells.
  • Fig. S4. The interaction between P-TEFb and Hexim1 is conserved in zebrafish.
  • Fig. S5. FP inhibits cystogenesis in the embryonic kidney model.
  • Fig. S6. Inhibition of CDK9 attenuates cyst development in the MDCK cyst model.
  • Fig. S7. HEXIM1 phosphorylation and P-TEFb/HEXIM1/7SK snRNP complex assembly in the MDCK cyst model.
  • Fig. S8. Effect of FP on cystogensis in the early- and late-onset ADPKD mouse models.

Download PDF

Files in this Data Supplement: