Science Advances

Supplementary Materials

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  • Fig. S1. Injury-induced microglia reactivity in WT and Sort1−/− lumbar spinal cord.
  • Fig. S2. Neurochemical markers remain intact in sortilin-deficient mice.
  • Fig. S3. Direct KCC2 inhibition induces pain hypersensitivity.
  • Fig. S4. Subcellular localization of TrkB is unchanged in SDH of sortilin-deficient mice.
  • Fig. S5. mRNA and protein levels of neurotensin and NTSR2 are unchanged in sortilin-deficient mice.
  • Fig. S6. Sortilin allows direct manipulation of the pain response to neuronal injury.
  • Fig. S7. Hum-sortilin-KI mouse model.

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