Science Advances

Supplementary Materials

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  • Fig. S1. Cancer cell lines exhibiting homozygous codeletions of p16/MTAP show altered patterns of metabolite levels.
  • Fig. S2. Responsiveness to methionine availability is not predicted by MTAP status.
  • Fig. S3. Responsiveness to alterations in other one-carbon nutrient availability is largely MTAP status independent.
  • Fig. S4. Restoration of MTAP expression produces heterogeneous effects on metabolism.
  • Fig. S5. MTAP status remains nonpredictive of responsiveness to nutrient restriction in a panel of tissue-matched cell lines.
  • Fig. S6. Gene expression does not strongly correlate with MTAP status or originating tissue in panel of 10 cell lines.
  • Table S1. Top 50 differential metabolites between MTAP+/+ and MTAP−/− cell lines.
  • Table S2. Top 50 differential metabolites between MTAP+/+ and MTAP−/− glioma cell lines.

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