Science Advances

Supplementary Materials

The PDF file includes:

  • Description of platinum complexes
  • Compiling all experimental data
  • Fig. S1. Results of cluster analysis of 25 compounds tested alone at 8 mg.
  • Fig. S2. Variable importance for the five models developed.
  • Table S1. List of 25 compounds tested alone at 8 mg with their respective clusters, LE and LC (minimum, maximum, mean, and SD values), LogP, MW, and number of performed experiments.
  • Table S2. List of three drugs with highest LE variability tested at 8 mg/ml.
  • Table S3. Statistical characteristics of LC and LE QSPR models based on fivefold external cross-validation.
  • Table S4. List of eight polymers used in this study with specification of block sizes and end group.
  • References (55, 56)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Curated solubilization data for a single drug or a two-drug combination loaded into polymeric micelles. This file contains all the data on compound solubilization generated in this study subject to curation protocols as described in Materials and Methods.

Files in this Data Supplement: