Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Detection of tau protein propagation using AAV GFP-2a-huTau.
  • Fig. S2. Unilateral expression of AAV GFP-2a-huTau in EC and HPC of the mouse brain.
  • Fig. S3. Labeling of areas connected to the AAV expression site in the EC.
  • Fig. S4. Tau propagates to distally connected areas after GFP-2a-WTtau expression in the EC.
  • Fig. S5. Enhanced misfolding in the absence of aggregation in P301Ltau-expressing EC neurons.
  • Fig. S6. Proteostasis, phospho-tau, and neurotoxicity markers in WTtau- and P301Ltau-expressing ECs.
  • Fig. S7. P301Ltau propagation, Western blots, and comparison of GFP-2a-P301Ltau expression in young and old mice.

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