Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Epididymal white adipose tissue mass in HFD WT and HHKO mice.
  • Fig. S2. Hepatocyte HIF-1α is not necessary for obesity-induced hepatic steatosis and inflammation.
  • Fig. S3. Dpp4 expression in different tissues from lean and obese mice.
  • Fig. S4. mRNA expression analysis in WT and HHKO mouse adipose tissue, liver, and primary hepatocytes.
  • Fig. S5. HIF-1α and its target gene expression in hepatocytes at different oxygen conditions or upon ACM or leptin + palmitic acid treatment.
  • Fig. S6. Schematic representation of a novel model of how obesity enhances GLP-1 inactivation and decreases incretin effects.
  • Fig. S7. Western blot analysis of phosphorylated p65 NF-κB expression in the liver of HFD WT and HAKO mice.
  • Fig. S8. Epididymal white adipose tissue expression of Hif1a, Epas1/Hif2a, and Dpp4 mRNAs.

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