Science Advances

Supplementary Materials

The PDF file includes:

  • Note S1. Pressure in the pump chamber and drug reservoir.
  • Note S2. Models for the radius of the cuff.
  • Note S3. Analytical model of contact pressure between the nerve and the cuff.
  • Note S4. Oxygen and hydrogen permeability of the flexible SBS membrane.
  • Note S5. Mechanical characterizations of optofluidic probe.
  • Note S6. Flow rate measurement.
  • Fig. S1. Images of the wireless electronics and the complete system.
  • Fig. S2. Detailed images of the electrochemical micropump.
  • Fig. S3. Modulus and water permeability of the flexible SBS membrane.
  • Fig. S4. Computational results for pressure in the pump chamber and the drug reservoir as a function of volume of drug delivered from the system.
  • Fig. S5. Demonstration of drug loading and device reuse.
  • Fig. S6. Mechanical properties of the soft opotofluidic probe.
  • Fig. S7. Measurements of nerve temperature during various μ-ILED illumination protocols.
  • Fig. S8. Diagrams of formation of cuff from bilayer PDMS strips.
  • Fig. S9. Mechanical characterizations of cuff.
  • Fig. S10. Demonstration of the dye delivery via the optofluidic cuff 2 weeks after implantation and the positive control PE tubing cuff implantation.
  • Fig. S11. Schematic illustrations of the metal membrane on the PI substrate.
  • Fig. S12. Schematic illustrations of the assembly of device.
  • Fig. S13. Isochoric gas permeation system.
  • Table S1. Oxygen and hydrogen permeability of the flexible SBS membrane.
  • Table S2. Fabrication process details.
  • Table S3. Statistical results for Fig. 3.
  • Table S4. Statistical results for Fig. 4.
  • Reference (47)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). The deformation of the flexible membrane.
  • Movie S2 (.mp4 format). The flow of fluid from the reservoir.
  • Movie S3 (.mp4 format). Mouse with a blue μ-LED during exercise on a running wheel.

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