Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Binding transitions obtained by HS-AFM.
  • Fig. S2. Dwell time distributions and the fitted time course of Pbound.
  • Fig. S3. Simulated binding transitions.
  • Fig. S4. The AgTx2 concentration dependence on kobs.
  • Fig. S5. Boltzmann‚Äôs H function.
  • Fig. S6. Dynamic disorder of binding transitions and correlation of individual Pbound values and interchannel distance.
  • Fig. S7. Dwell time distributions obtained by dwell time analysis, event-oriented analysis, and correlation function.
  • Fig. S8. Removing fluctuations in the baseline.
  • Reference (61)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). HS-AFM movie of AgTx2 binding on the KcsA channels.
  • Movie S2 (.mp4 format). HS-AFM movie showing dynamic disorder of binding transitions.

Files in this Data Supplement: