Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. The synthesis of cRGD peptide with PEG-DSPE assayed by MALDI-TOF.
  • Fig. S2. TEM photos and size distribution of various liposomes.
  • Fig. S3. Particle size of PLs/cRGDLs in different positon of the suspension or different medium by dynamic light scattering at different time.
  • Fig. S4. Derived count rate of PLs/cRGDLs in different positon of the suspension or different medium by dynamic light scattering at different time.
  • Fig. S5. The influence of liposomes and antibodies on the migration of M/Ns.
  • Fig. S6. Location of liposomes in ischemic brains of I/R rats 12 hours after reperfusion.
  • Fig. S7. Confocal microscope images of comigration of Cy5-PLs/Cy5-cRGDLs with M/Ns across cerebral vessels in the nonischemic hemisphere 24 hours after reperfusion.
  • Fig. S8. Transfer mechanisms of the liposomes from immune cells to neuron cells.
  • Fig. S9. TEERs of HBMEC in comigration and inhibition assay.
  • Fig. S10. Confocal microscope images of cellular location of Cy5-NBD-cRGDLs in M/Ns.
  • Table S1. Characterization of all liposomes used in the study.
  • Table S2. The pharmacokinetics parameters of I125-labeled PG.
  • Reference (41)

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