Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. nIRCats are compatible with concentrations and conditions expected in brain tissue.
  • Fig. S2. Surface-immobilized single nIRCats are reversible upon repeat exposure to DA.
  • Fig. S3. Brain slice nIRCat loading protocol and schematic of visible and nIR fluorescence microscopy for imaging nIRCats in brain tissue.
  • Fig. S4. nIRCat imaging in M. spicilegus brain tissue.
  • Fig. S5. Intensity of nIRCat labeling at baseline does not predict site of ∆F/F hotspots.
  • Fig. S6. Variability in effect of quinpirole and sulpiride on nIRCat response on spatially segregated ROIs within a field of view.
  • Fig. S7. Data that confirm targeting of optogenetic stimulation of dopaminergic and glutamatergic inputs to the striatum.
  • Fig. S8. Effect of quinpirole on ChR2 evoked nIRCat response at the level of ROIs.
  • Fig. S9. Nomifensine extends nIRCat response to ChR2 stimulation of dopaminergic terminals in the dorsal striatum.

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). A representative movie from single-pulse electrical stimulation (0.3 mA) in dorsal striatum.
  • Movie S2 (.avi format). A representative movie from optogenetic stimulation (five pulses at 25 Hz, 1 mW mm2) in dorsal striatum.

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