Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. Representative immunohistochemistry stain for CCHFV N protein in livers and spleens of mice.
  • Fig. S2. GP38 amino acid differences between CCHFV strains IbAr 10200 and Afg09-2990.
  • Fig. S3. Combined ISH analysis of CCHFV strain IbAr 10200– and Afg09-2990–infected mice treated with mAb-13G8.
  • Fig. S4. Combined hematoxylin and eosin liver analysis of CCHFV strain IbAr 10200– and Afg09-2990–infected mice treated with mAb-13G8.
  • Fig. S5. Combined hematoxylin and eosin spleen analysis of CCHFV strain IbAr 10200– and Afg09-2990–infected mice treated with mAb-13G8.
  • Fig. S6. CCHFV lethality in IFN-I–blocked BALB/c and C57BL/6 mice.
  • Fig. S7. 10E11 binds GP38 but does not protect against lethal disease in IFNAR−/− mice.
  • Fig. S8. CCHFVLP neutralization by select mAbs with and without complement.
  • Fig. S9. GP38 binding of mouse and rabbit sera.
  • Table S1. Histopathology summary.

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