Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Neu1−/− muscles have increased levels of TGF-β and WNT signaling components.
  • Fig. S2. Neu1−/− muscles show increased levels of periostin and osteopontin.
  • Fig. S3. WB analyses of WT and Neu1−/− (myo)fibroblast lysates.
  • Fig. S4. Neu1−/− muscle and myofibroblasts up-regulate canonical markers that drive an EMT process.
  • Fig. S5. Characterization of WT and Neu1−/− exosomes.
  • Fig. S6. Neu1−/− exosomes contain increased levels of components of the TGF-β and WNT signaling pathways.
  • Fig. S7. NEU1-deficient exosomes induce a fibroblast to myofibroblast program in recipient normal fibroblasts.
  • Fig. S8. General fibrosis in the Neu1−/− mouse model and decreased NEU1 protein levels in IPF fibroblasts.
  • Table S1. Murine and human RT-qPCR primers.
  • Table S2. Comparative high-throughput proteomic analyses of Neu1−/− and WT exosomes.

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