Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. In vitro different cell viability cocultured with different particles and tumor inhibition in vivo.
  • Fig. S2. The ultrastructure of tumor tissues treated with n-HA observed by TEM.
  • Fig. S3. H&E staining and immunohistochemical analyses of tumor tissues.
  • Fig. S4. Quantification of immunohistochemical staining of Ki-67, Tunel, p53, Cyt C, Bcl-2, and Bax expression of tumor tissues treated with n-HA during weeks 2 to 5.
  • Fig. S5. GSEA and protein-protein interaction analysis.
  • Fig. S6. Animal body weight changes, tumor metastasis, and biosafety analysis of n-HA/scaffold.
  • Table S1. Abbreviations and full names of genes labeled in the volcano plot.
  • Table S2. Positive enrichment of mRNA expression profile in microarray analysis (n-HA versus control).

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