Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Treg surface markers remain decreased in Bcl11b KO Treg cells in tumors.
  • Fig. S2. Bcl11b KO Treg cells in Rag1−/− mice transferred with CD45Rbhi CD4+ T cells to induce colitis.
  • Fig. S3. Bcl11b controls similar pathways during steady state and inflammation.
  • Fig. S4. Top Bcl11b ChIP-seq binding motifs in mice and human Treg cells.
  • Fig. S5. Bcl11b and Foxp3 interact in a subset of Treg cells.
  • Fig. S6. Bcl11b binds at key Treg gene superenhancers.
  • Table S1. WT and KO Treg phenotype in EAE and tumor compared with steady-state Treg cells.
  • Table S2. Top 10 motifs found in peaks annotating to up-regulated and down-regulated genes.
  • Table S3. Treg signature genes commonly bound by Bcl11b and Foxp3 in Treg cells.
  • Table S4. Antibodies used for flow cytometry staining and ChIP-seq.

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