Science Advances

Supplementary Materials

This PDF file includes:

  • Table S1. MANT-GDP dissociation rates of the wild type and the N92I mutant in the presence of various concentrations of Mg2+.
  • Table S2. MANT-GDP dissociation rates of the mutants of the residues from the α3 helix and the switch 2 region.
  • Table S3. MANT-GDP dissociation rates of the mutants of Asn92.
  • Fig. S1. Comparisons of the structures of Rac between the RhoGDI-bound state and the uncomplexed state.
  • Fig. S2. Microsecond-order conformational exchange processes in the wild type and the N92I mutant.
  • Fig. S3. Secondary structure populations of the wild type and the N92I mutant.
  • Fig. S4. Structural characterizations of the P-loop.
  • Fig. S5. Mant-GDP dissociation rates in the presence of guanidine hydrochloride.
  • Fig. S6. Temperature-dependent changes in the 1H-15N TROSY spectra.
  • Fig. S7. Characterizations of the structure and conformational stability of the W97A mutant.

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