Science Advances

Supplementary Materials

This PDF file includes:

  • Supplemental Experimental Details
  • Fig. S1. Determination of SBP2 expression in SBP2 tissue.
  • Fig. S2. SBP2 expression controls the phenotype polarization of ATMs.
  • Fig. S3. SBP2 overexpression had no significant effect on the lysosome exocytosis of MMe.
  • Fig. S4. Glucan-mediated macrophage-targeted delivery specifically suppressed SBP2 in ATMs.
  • Fig. S5. SBP2 suppressed activation of caspase-1 by the inflammasome.
  • Fig. S6. Eight-week knockdown of SBP2 in ATMs accelerated insulin resistance in DIO mice but not in diabetic db/db mice (n = 6).
  • Fig. S7. SBP2 knockdown in ATMs produced a more pronounced effect in male mice than female mice.
  • Fig. S8. Chemical and safety analysis of TNTL.
  • Table S1. Basic information of patients observed in the study.
  • Table S2. Primers to be used for quantitative reverse transcription polymerase chain reaction.

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