Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Confirmation of CBD fusion to SA by MALDI-TOF MS analysis.
  • Fig. S2. Binding affinities of CBD-SA to collagen type I and type III.
  • Fig. S3. SDS-PAGE analysis of mouse SA and CBD-SA conjugated with Dox.
  • Fig. S4. Hydrodynamic sizes.
  • Fig. S5. The binding interface between collagen type III and A3 domain of VWF.
  • Fig. S6. In vitro release kinetics of Dox from Dox-SA.
  • Fig. S7. Plasma pharmacokinetics of DyLight 800–labeled SA and CBD-SA.
  • Fig. S8. Changes of hematological values in mice receiving aldoxorubicin or Dox-CBD-SA (20 mg/kg).
  • Fig. S9. Histological analysis of major organs after Dox-CBD-SA treatment.
  • Fig. S10. MC38 tumor rechallenge and body weight changes of MC38 tumor-bearing mice during the treatment.
  • Table S1. Amino acid sequence of CBD-SA.

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