Science Advances

Supplementary Materials

The PDF file includes:

  • Supplementary Results
  • Fig. S1. Reaction kinetics of the thiol-to-amine cyclization reaction.
  • Fig. S2. Thiol-to-nitrogen cyclization reagents and side products.
  • Fig. S3. Scaffold diversity in pilot-scale macrocycle library.
  • Fig. S4. Characterization of trypsin and thrombin hits.
  • Fig. S5. KLK5 screen and HPLC analysis of thrombin hits.
  • Fig. S6. Structures, HPLC analysis, and activities of macrocycles.
  • Fig. S7. Chemical structure of P2.
  • Table S1. Chemical structures and codes of amino acids.
  • Table S2. Statistics on x-ray structure data collection and refinement.
  • Table S3. Interactions between P2 and thrombin.
  • Legends for data S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Data S1 (.pdf file). Raw data of peptide macrocyclization reactions.
  • Data S2 (.pdf file). Poster showing all 432 different macrocycle scaffolds in the pilot-scale library.

Files in this Data Supplement: