Science Advances

Supplementary Materials

The PDF file includes:

  • Supplementary Text
  • Fig. S1. The distribution of the target diagnoses in premutation carriers and controls for codes received before age 60.
  • Fig. S2. The distribution of the target diagnoses in premutation carriers and controls for codes received before age 80.
  • Fig. S3. The distribution of the target diagnoses in premutation carriers and controls based on lifetime diagnoses.
  • Fig. S4. Manhattan plots of unadjusted −log10 (P values) for phecodes observed before age 60.
  • Fig. S5. Manhattan plots of unadjusted −log10 (P values) for phecodes observed before age 80.
  • Fig. S6. Manhattan plots of unadjusted −log10 (P values) for lifetime phecodes.
  • Table S1. Phenotypic association with FMR1 premutation reported in published literature, identified by KinderMiner.

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Other Supplementary Material for this manuscript includes the following:

  • Data S1 (Microsoft Excel file). Lists of the first 100 variables that contributed in the classification of female premutation carriers (n = 72) versus control (n = 507).
  • Data S2 (Microsoft Excel file). Lists of the first 100 variables that contributed in the classification of male premutation carriers (n = 26) versus control (n = 494).
  • Data S3 (Microsoft Excel file). Linear regression models based on PheWAS phenotypes of female participants.
  • Data S4 (Microsoft Excel file). Linear regression models based on PheWAS phenotypes of male participants.

Files in this Data Supplement: