Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Purification of CD4 T cells from young and old mice.
  • Fig. S2. Dimensionality reduction of scRNA-seq data.
  • Fig. S3. Subset identity and abundance in mice used for scRNA-seq.
  • Fig. S4. RECs activation state and correlation with serum cytokines.
  • Fig. S5. RECs abundance with time and across different immunological sites.
  • Fig. S6. Gene regulatory networks and cytokine secretion in RECs.
  • Fig. S7. Characterization of T helper polarizations within RECs.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). The number of cells per mouse before and after quality control.
  • Table S2 (Microsoft Excel format). Subset and age-group expression of genes.
  • Table S3 (Microsoft Excel format). RECs comparison to closely related subsets.

Files in this Data Supplement: