Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Characterization of HBBA and quantification of the SBA and HBBA displays.
  • Fig. S2. TSA and THA efficiently bind biotinylated molecules in vitro.
  • Fig. S3. Recombinant AAV (serotype DJ) efficiently attaches to T4 capsid through biotin-avidin cross-bridges.
  • Fig. S4. Characterization of T4 DNA packaging.
  • Fig. S5. The T4-AAV vector efficiently delivers packaged DNAs and displayed proteins into mammalian cells without affecting cell viability.
  • Fig. S6. Endosomal escape is critical for T4-AAV intracellular delivery.
  • Fig. S7. Representative in vivo bioluminescence images of mice at various time points.
  • Fig. S8. DNA packaging, protein expression, and antigen delivery by the T4-AAV vector.
  • Fig. S9. In vivo toxicity measurement of T4-AAV particles.
  • Table S1. Comparison of T4 nanoparticle delivery with other viral delivery platforms.

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