Science Advances

Supplementary Materials

This PDF file includes:

  • Section S1. Depletion, diffusion, and concentration of hemoglobin near a growing fiber
  • Section S2. Polymerization of deoxygenated HbS
  • Section S3. Sensitivity analysis of RBC sickling criterion
  • Section S4. Sickling of patient-specific RBCs in microfluidic channel under hypoxia
  • Section S5. Determinants of RBC sickling time in the kinetic model
  • Section S6. Model parameters
  • Section S7. Model inputs
  • Fig. S1. Detailed flow chart of the kinetic model.
  • Fig. S2. Predicted nucleation barriers near a growing fiber.
  • Fig. S3. Simulation of HbS polymerization in purified HbS solution.
  • Fig. S4. Sensitivity of model predictions.
  • Fig. S5. Evolution of fractions of sickled RBCs under hypoxia for seven SCD patients.
  • Fig. S6. Cumulative contributions to the RBC sickling time factors 1 to 5.
  • Table S1. Patient-specific RBC variables for seven SCD patients examined in (24).
  • Table S2. The default values of model parameters and their varying ranges in the sensitivity analysis.
  • Table S3. Three sets of model inputs following the in vivo study (20) (condition I), in vitro study (24) (condition II), and the screening assay (22) (condition III).
  • References (4045)

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