Science Advances

Supplementary Materials

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  • Fig. S1. KSHV helicase and cellular DNA helicase MCM7 are evolutionarily conserved.
  • Fig. S2. KSHV helicase is critical for viral DNA replication.
  • Fig. S3. Viperin is critical for viral DNA replication and KSHV-encoded RTA binds to viperin promoter to up-regulate viperin expression.
  • Fig. S4. Viperin promotes methionine oxidation of KSHV helicase.
  • Fig. S5. Viperin-induced methionine-401 oxidation enhances the stability and function of KSHV helicase.
  • Fig. S6. Viperin associates with lipid droplets that are required to induce the methionine oxidation of KSHV helicase.
  • Fig. S7. Viperin-induced methionine oxidation stabilizes MCM7 and promotes DNA replication.
  • Fig. S8. Viperin interacts with several DNA helicases.
  • Fig. S9. Methionine oxidation catalyzed by viperin increases the stability and function of RNA helicase RIG-I.
  • Table S1. Amino acid sequence alignment for each human DNA helicase with KSHV helicase.

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