Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Effect of ITGA5 knockdown in hPSCs on α-SMA, collagen I expression, and downstream genes.
  • Fig. S2. Effect of ITGA5 blocking peptidomimetic (AV3) (related to Fig. 4).
  • Fig. S3. AV3 reduces PSC-induced pancreatic tumor growth in the subcutaneous co-injection (PANC-1 + hPSCs) pancreatic tumor model.
  • Fig. S4. Effect of AV3 in PANC-1 and MIA PaCa-2 tumor models.
  • Fig. S5. Characterization of human pancreatic tumor tissue for PDX and PDX models.
  • Table S1. Characteristics for PDAC patients.
  • Table S2. Univariable and multivariable Cox proportional hazard model predictive value of ITGA5 expression on OS of patients with PDAC.
  • Table S3. Primers used for quantitative real-time PCR.
  • Table S4. Details of the antibodies used for Western blot analyses.

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). The complete gene array data on sh-ITGA5 hPSCs versus sh-NC and the effect of TGF-β activation on sh-NC and sh-ITGA5 hPSCs.

Files in this Data Supplement: