Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Representation of the top active MRs identified in the CMC data.
  • Fig. S2. GOSlim summary of the up-regulated genes on day 3.
  • Fig. S3. GOSlim summary of the down-regulated genes on day 3.
  • Fig. S4. GOSlim summary of the up-regulated genes on day 14.
  • Fig. S5. GOSlim summary of the down-regulated genes on day 14.
  • Fig. S6. Biological pathways altered upon TCF4 knockdown in hiPSC-derived neuronal cells.
  • Fig. S7. MetaCore analysis of top 2000 dysregulated genes upon TCF4 knockdown in hiPSC-derived neurons.
  • Fig. S8. MetaCore analysis of all gene sets dysregulated upon TCF4 knockdown in hiPSC-derived neurons.
  • Fig. S9. The identified TCF4 interactome and their contributions to expression of TCF4.
  • Fig. S10. Batch correction of CD07 cell line data.
  • Fig. S11. Correlations between the expression profile (summarized as median gene expression of each gene across samples) of the CMC, CNON, and NPC data with the 53 tissues from the GTEx consortium.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Targets of the identified hub genes in the CMC network.
  • Table S2 (Microsoft Excel format). Network structure created from the CMC data.
  • Table S3 (Microsoft Excel format). Network structure created from the CNON data.
  • Table S4 (Microsoft Excel format). Targets of the identified hub genes in the CNON network.
  • Table S5 (Microsoft Excel format). Targets of five MRs in the CMC and CNON data.
  • Table S6 (Microsoft Excel format). List of the altered pathway upon TCF4 knockdown in NPCs and Glut_Ns in the SCZ cell line.
  • Table S7 (Microsoft Excel format). List of differentially expressed genes in NPCs and Glut_Ns in the SCZ cell line.
  • Table S8 (Microsoft Excel format). MetaCore enrichment analysis on NPCs in the SCZ cell line.
  • Table S9 (Microsoft Excel format). MetaCore enrichment analysis on Glut_Ns in the SCZ cell line.
  • Table S10 (Microsoft Excel format). List of TCF4 targets in other studies.
  • Table S11 (Microsoft Excel format). VIPER enrichment scores of the identified MRs in the CMC and CNON data.

Files in this Data Supplement: