Science Advances

Supplementary Materials

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  • Fig. S1. Relative QYs of IR-783, IR-12N3, and ICG in BSA/FBS, depicted by the slope of fluorescence intensity versus absorption.
  • Fig. S2. Method optimization for the fluorophore@BSA complex.
  • Fig. S3. The optimization for ratio and reaction concentration of BSA and IR-783.
  • Fig. S4. Stability, brightness, and size of the IR-783@BSA complex at 1:0.5, 1:1, and 1:2 ratios.
  • Fig. S5. Docking simulation and computational modeling demonstrating the binding poses and the mechanism of increased QY for complexation.
  • Fig. S6. The free IR-12N3/ICG/IR-783 has quick hepatobiliary clearance and short imaging window compared to their complex with albumin.
  • Fig. S7. Comparison of the vessel imaging time window of free IR-783 with the IR-783@BSA complex.
  • Fig. S8. Further imaging comparison of IR-783@BSA from different conditions (C2, C3, and C4).
  • Fig. S9. NIR-II QY of the IR-783@BSA complex and NIR-II vessel imaging in whole-body mode.
  • Fig. S10. The IR-783@Erbitux complex afforded an efficient conjugate and decent targeting ability for molecular imaging.
  • Table S1. The excitation energies for both vertical excitation and emission computed using TDDFT/IEFPCM in complex mode.
  • References (4152)

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