Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. iP300w protects 293T cells from DUX4-induced toxicity.
  • Fig. S2. Doxycycline effect on morphology and viability of parent cell lines.
  • Fig. S3. iP300w inactivates induction of DUX4 target genes.
  • Fig. S4. iP300w inactivates induction of DUX4 target genes in different cell types.
  • Fig. S5. Dose- and time-dependent DUX4 inactivation by iP300w in FSHD myoblasts.
  • Fig. S6. Effect of doxycycline on profibrotic gene expression in wild-type mice.
  • Fig. S7. Low levels of DUX4 induce H3 acetylation through p300 in human myoblasts.
  • Fig. S8. DUX4 induces H3 acetylation in nonmyogenic cells.
  • Fig. S9. Low levels of DUX4 induce H3 acetylation through p300 in mouse myoblasts.

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