Science Advances

Supplementary Materials

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  • Fig. S1. Metformin at 1 μM increases the number of neurospheres in an age- and sex-dependent manner.
  • Fig. S2. Metformin has no effect on the number of neurospheres from the adult male SVZ regardless of metformin dose or duration of treatment.
  • Fig. S3. The absolute number of neurospheres is the same in male and female C57 mice at each age examined.
  • Fig. S4. Lack of sex-dependent effects of estradiol and testosterone on primary and secondary neurospheres from the SVZ of adult female and male mice.
  • Fig. S5. Testosterone and metformin eliminate the effect of metformin on NPCs in the female SVZ.
  • Fig. S6. Motor impairments do not account for the deficits in task acquisition in females and males.

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