Science Advances

Supplementary Materials

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  • Fig. S1. Roles of CerS1 versus CerS6 in ceramide generation and mitophagy induction.
  • Fig. S2. CerS1 amino acids 60 to 76 are critical for Cers1 import to mitochondria.
  • Fig. S3. Ceramide transport by CERT or FAPP2 is not involved in mitophagy.
  • Fig. S4. CerS1 mitochondrial import is mediated by p17/PERMIT.
  • Fig. S5. Mitochondrial import of CerS1 requires p17/PERMIT and involves amino acids RYE28-30.
  • Fig. S6. p17/PERMIT-mediated CerS1 import to mitochondria induces mitophagy.
  • Fig. S7. Roles of Drp1 nitrosylation at C644 in mitochondrial localization of CerS1.
  • Fig. S8. Mitochondrial localization of CerS1 induces mitophagy via ATG, LC3, and Drp1 in response to SoSe.
  • Fig. S9. Mitochondrial CerS1-dependent mitophagy is induced via activation of LC3 and Drp1.
  • Fig. S10. Summary of the hypothesis and proposed mechanism for the mitochondrial trafficking of CerS1 by p17/PERMIT.

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