Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Alignment of orthologous Vn sequences.
  • Fig. S2. Alignment of the HX domains of human Vn, rabbit hemopexin, and human matrix metalloproteases.
  • Fig. S3. HX repeat and intron/exon structures of human Vn, hemopexin N- and C-terminal domains, and matrix metalloproteases.
  • Fig. S4. Structure, B factors, and surface electrostatics of Vn-HX.
  • Fig. S5. Geometry of the ion-binding sites in the central channel of Vn-HX.
  • Fig. S6. Conserved prolines stabilize outward facing aromatic side chains.

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