Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. Histology, oxidative stress, and inflammation in the skin of WT, Abcg2-null, Fech-mut, and Fech-mut/Abcg2-null mice after the exposure to UV light (395 to 410 nm).
  • Fig. S2. Gross appearance of Fech-mut and Fech-mut/Abcg2-null mice before and after exposure to red light (630 nm).
  • Fig. S3. Fluorescence of liver samples from WT, Abcg2-null, Fech-mut, and Fech-mut/Abcg2-null mice.
  • Fig. S4. Evaluation of liver fibrosis in WT, Abcg2-null, Fech-mut, and Fech-mut/Abcg2-null mice.
  • Fig. S5. ABCG2 deficiency abolishes GSF-induced PPIX accumulation and hepatotoxicity.
  • Fig. S6. Effects of ABCG2 deficiency on the expression of efflux transporters in the liver.
  • Fig. S7. Identification of PPIX-glu.
  • Fig. S8. Hematological analysis of blood samples from WT, Abcg2-null, Fech-mut, and Fech-mut/Abcg2-null mice.
  • Fig. S9. The ratios of spleen to body weight and PPIX levels in the spleen of WT, Abcg2-null, Fech-mut, and Fech-mut/Abcg2-null mice.
  • Table S1. Primers for quantitative PCR analysis.

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