Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. X. laevis and human Bap1 proteins show extensive sequence homology.
  • Fig. S2. Anatomic distribution of Xenopus bap1 mRNA and Bap1 protein expression during early development.
  • Fig. S3. Bap1 morpholinos and expression constructs.
  • Fig. S4. Developmental abnormalities in Bap1-deficient embryos are rescued by exogenous human BAP1.
  • Fig. S5. Loss of Asxl1 phenocopy loss of Bap1 during Xenopus development.
  • Fig. S6. Pharmacologic rescue of Bap1-deficient phenotype.
  • Fig. S7. Hdac4 is a key mediator of Bap1-deficient phonotype and acts independently of Hdac3 during development.
  • Fig. S8. Inhibition of HDAC4 significantly impairs proliferation of uveal melanoma cells in a BAP1-dependent manner.
  • Legends for data files S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Oligonucleotides and plasmids used in this study.
  • Data file S2 (Microsoft Excel format). Proteomic, transcriptomic, and epigenomic analyses.

Files in this Data Supplement: