Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Palbociclib-resistant melanoma cells retain broad resistance to CDK4/6i or CKD4/6i’s.
  • Fig. S2. Analyses of WM3918, TE7, and TE10 cells with CDK4/6i resistance.
  • Fig. S3. Different acquired resistance mechanisms between 1205CR1-2 and 1205CR6-7 cells.
  • Fig. S4. Overexpression of CDKs does not override CDK4/6i-induced senescence in melanoma.
  • Fig. S5. The impacts of adding amino acids and SLC36A1 in the context of CDK4/6i-induced senescence.
  • Fig. S6. FXR1 regulates SLC36A1 protein expression.
  • Fig. S7. FXR1 overrides CDK4/6i-induced senescence.
  • Fig. S8. RNA-seq analysis of additional cancers with CDK4/6i resistance.

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